Review Paper: Treat Liver To Beat Diabetes

Abstract: Management of Type 2 Diabetes (T2DM) with existing strategies of lifestyle and pharmaceutical interventions has gained limited success as evidenced by its uncontrolled progression. Two key organs which are involved in the pathophysiology of T2DM are liver and pancreas, both are the derivatives of endoderm with a common precursor. In the invertebrates, hepatopancreas performs the function of both liver and pancreas. It is known that derangement in glycolysis, neoglucogenesis, and glycogenolysis lead to hyperglycemia in T2DM although insulin levels are high. Several studies have reported the implication of abnormal liver function in the development of metabolic syndrome i.e. T2DM. Partial hepatectomy has been shown to improve glycemic status in animal models of diabetes. This could be because liver and pancreas share the same regenerating factors. These evidences suggest that abnormal liver status can impair pancreatic beta-cell function and survival along with peripheral insulin resistance. We, therefore, hypothesize that restoring deranged liver functions may aid in the better control and management of T2DM. If found true, it may shift the current intervention strategy towards liver rather than pancreas in the treatment of T2DM.

Journal: Medical Hypotheses

Keywords: Type 2 DiabetesLiver dysfunctionPancreasIntra-organ communication
  


Comments

  1. I am impressed by the original and new thought process ignited by you.
    Certainly experiments and studies will help the suffering diabetecs.
    Meanwhile, one can start the basic studies in liver donors immediately without much hesitation.+
    Well, all the best and certainly no words can praise you sufficiently,

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    Replies
    1. Thank yo very much for you kind appreciative words. I would like to give the credit to Dr. Ramesh Bhonde, my guide, for this provoking idea. And yes, truly said, the studies in liver donors can be initiated and if this turns out positive. it will be a breakthrough for the management of type 2 diabetes.

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  2. Thanks for sharing useful information.

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Dr. Shivani Desai
Pune, India
Clinical Pharmacologist | Pharmaceutical Sciences Doctorate | Type 1 Diabetes Researcher | Assistant Professor | Basket Ball Player | Gold Medalist Painter