Showing posts with label Pharmaceutical Resonance. Show all posts
Showing posts with label Pharmaceutical Resonance. Show all posts
Abstract: Type 1 diabetes mellitus (T1DM), an autoimmune disease, leads to obliteration of
pancreatic β-cells, and hence causes insufficient production of insulin. With many other etiological factors, antibiotic use and gut microbiota have a significant role to play in its development. The gut microbiota interacts with the cells involved in innate immunity and has a significant role in determining the immune system. Several factors such as mode of birth, infections, diet, and medication including antibiotics influence the microbiota composition. Alterations and manipulation of microbiota in animal models have been shown to affect the onset and incidence of diseases having multifactorial etiology, like T1DM. Hence, the microbiota is an integral part that influences the innate immune cells and this microbiota is influenced by the use of antibiotics. This review discusses the studies in relation to microbiota and antibiotic use with reference to T1DM.
Journal: Pharmaceutical Resonance
Keywords: Type 1 diabetes mellitus; Antibiotics; Microbiota; Innate immunity
Abstract: Diabetes mellitus is a common metabolic disorder affecting a wide range of populations worldwide. There are many types of diabetes mellitus, one of which is type 1 diabetes mellitus (T1DM). It is an autoimmune disorder caused in about 97,700 children in India and 490,000 children globally. Many etiological factors contribute to this disease. This review article is a collage of etiological factors causing T1DM. A better understanding of aetiology is significant for the prevention and management of the disease.
Keywords: Type 1 Diabetes Mellitus; Etiology; Autoantibodies; Extracellular matrix; Coxsackievirus B virus
[Review Paper] A Peripheral Concept On Aetiology Of Type 1 Diabetes Mellitus
Dr. Shivani Desai
November 10, 2019
![[Review Paper] A Peripheral Concept On Aetiology Of Type 1 Diabetes Mellitus](https://1.bp.blogspot.com/-ubZrSdNegm4/YCqjBWpDiCI/AAAAAAAAE8c/vAH2OHFLqaIU8YDVO24McvbFTVdpOArKgCLcBGAsYHQ/s72-c/A%2BPERIPHERAL%2BCONCEPT%2BON%2BAETIOLOGY%2BOF%2BTYPE%2B1%2BDIABETES%2BMELLITUS.png)