A FORUM TO

TYPE 1 DIABETES MELLITUS

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A Step Into Freedom From Type 1 Diabetes

T1DM.org

T1DM.org is a platform which consolidates the author’s work about type 1 diabetes and its management. This forum invites an open interaction from national and international experts to manage type 1 diabetes, share their knowledge and collaborate to work towards freedom from this painful disease.

This forum only includes the papers published by the author in the journals of repute at the moment. These papers primarily involve the content related to the etiology and pathophysiology of T1DM, application of mesenchymal stem cells to manage T1DM and improve the quality of life in patients, and about the correlation of diabetes with hepatic dysfunctions. However, it will soon come up with the papers related to the immunomodulatory aspects in the journey to prevent and reverse the disease.

With more interaction and collaborations, we can bring an end to T1DM and give a better life to the children who are at risk to develop this immensely agonising disease.

Contact Us Publications

OUR APPROACH

1. In-vitro Study

Test the immunological reactions

2. Preclinical Study

Test the immunological responses in animal model

3. Formulation

Prepare a potential formulation candidate based on results and tests in in-vivo

4. Clinical Study

Clinical evaluation of the potential formation for T1DM
OUR T1DM PUBLICATIONS
All Research Articles Review Articles Videos
Showing posts with label Review. Show all posts
Showing posts with label Review. Show all posts

[Review Paper] Type 1 Diabetes and Covid-19: Managing the Difficult Duo

Coronavirus disease 2019 (COVID-19) has stimulated health concerns globally, especially in diabetes where it has been accompanied by severe outcomes.

Type 2 diabetes mellitus (T2DM) is a chief worry; though, there are a considerable population of patients with type 1 diabetes mellitus (T1DM) also, that too with incomparable concerns during the current COVID-19 pandemic. Some children experience significant complications related to this disease and paediatric deaths have also been reported.

This article describes some key points related to the complications and management of concomitant T1DM and COVID-19.

[Review Paper] Polyvaccine - Joining The Links In The Cascade Of Type 1 Diabetes

Abstract: The incidence of type 1 diabetes mellitus (T1DM), an autoimmune disorder, has ascended considerably with around 98,200 and 15,900 incidents in children below 15 years of age, globally and in India, respectively. This is typically due to environmental changes leading to genetic modifications. Also, T1DM encompasses the presence of autoantigens and many other etiologies which can be targeted by proper immunization. In this paper, we consciously discuss and collate various candidate triggers of islet autoimmunity and other factors expected to promote the progression of T1DM. This paper bridges all the mechanisms caused by these factors and linking them with each other. We have also highlighted the novel coronavirus as a trigger for T1DM. Finally, we suggest that an amalgamated model of polyvaccine can batter the condition by inducing protection against various triggers of T1DM.

Journal: Clinical and Experimental Vaccine Research 


Keywords: Type 1 diabetes mellitus; Viruses; Coronavirus; Cow's milk; Hybrid insulin peptides; Vaccines


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[Review Paper] Stem Cells - A Golden Therapy for Diabetic Wound

Abstract: Diabetes mellitus is the 7th leading cause of death worldwide. Diabetes can affect the organ systems and lead to a serious complication, majorly categorized as macrovascular complications, microvascular complications, and diabetic wound. Foot ulcer develops in 15-25% diabetic patient. In diabetic wound, there is impairment in growth factor, neuropeptide, matrix metalloproteinases, angiogenesis, immune system. Many approaches are being experimented to manage this major complication of the diabetic foot, but unfortunately with lesser success rate. A stem cell is an upcoming field which is being explored in the world of diabetes. Hence, this review is designed to understand the basic pathogenesis and complications of types of diabetes and the role of stem cells in the diabetic wound and the benefits related to it.


Journal: Current Diabetes Reviews 


Keywords: Angiogenesis; Diabetes mellitus; Diabetic complications; Foot ulcer; Stem cells


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[Review Paper] Antibiotics - A Boon Or Tragedy For Type 1 Diabetes?

Abstract: Type 1 diabetes mellitus (T1DM), an autoimmune disease, leads to obliteration of
pancreatic β-cells, and hence causes insufficient production of insulin. With many other etiological factors, antibiotic use and gut microbiota have a significant role to play in its development. The gut microbiota interacts with the cells involved in innate immunity and has a significant role in determining the immune system. Several factors such as mode of birth, infections, diet, and medication including antibiotics influence the microbiota composition. Alterations and manipulation of microbiota in animal models have shown to affect the onset and incidence of disease having multifactorial etiology, like T1DM. Hence, the microbiota is an integral part which influences the innate immune cells and this microbiota is influenced by the use of antibiotics. This review discusses the studies in relation to the microbiota and antibiotic use with reference to T1DM.




Journal: Pharmaceutical Resonance 

Keywords: Type 1 diabetes mellitus; Antibiotics; Microbiota; Innate immunity

[Review Paper] Wound With Diabetes - Present Scenario And Future

Abstract: Diabetes is a chronic metabolic disorder of the endocrine system characterized by an increase in blood glucose level. Several factors such as pancreatic damage, oxidative stress, infection, genetic factor, obesity, liver dysfunction play a vital role in the pathogenesis of diabetes which further leads to serious diabetic complications. The diabetic wound is one such complication where the wound formation occurs, especially due to pressure and its healing process is disrupted due to factors such as hyperglycemia, neuropathy, nephropathy, peripheral vascular disease, reduction of blood flow, atherosclerosis, impaired fibroblast. Process of wound healing is delayed due to different abnormalities like alteration in nitric oxide level, increase in aldose reductase, sorbitol and fructose. Therefore, diabetic wound requires more time to heal as compared to a normal wound. Healing time is delayed in diabetic wound due to many factors such as stress, decreased oxygenation supply, infection, decreased blood flow, impaired proliferation and migration rate, impaired growth factor production, impaired keratinocytes proliferation and migration, and altered vascular endothelial mediators. The current treatment for diabetic wound includes wound patches, oxygenation therapy, hydrogel patches, gene therapy, laser therapy, and stem cell therapy. Medications with phytoconstituents are also one way to manage the diabetic wound, but it is not more effective for quick healing. The objective of this review is to understand the potential of various management options which are available for diabetic wound, with a special focus on biological cells.




Journal: Current Diabetes Review

Keywords: Angiogenesis; Diabetic wound; Growth factors; Stem cells; Wound healing

[Review Paper] Treat Liver To Beat Diabetes

Abstract: Management of Type 2 Diabetes (T2DM) with existing strategies of lifestyle and pharmaceutical interventions has gained limited success as evidenced by its uncontrolled progression. Two key organs which are involved in the pathophysiology of T2DM are liver and pancreas, both are the derivatives of endoderm with a common precursor. In the invertebrates, hepatopancreas performs the function of both liver and pancreas. It is known that derangement in glycolysis, neoglucogenesis, and glycogenolysis lead to hyperglycemia in T2DM although insulin levels are high. Several studies have reported the implication of abnormal liver function in the development of metabolic syndrome i.e. T2DM. Partial hepatectomy has been shown to improve glycemic status in animal models of diabetes. This could be because liver and pancreas share the same regenerating factors. These evidences suggest that abnormal liver status can impair pancreatic beta-cell function and survival along with peripheral insulin resistance. We, therefore, hypothesize that restoring deranged liver functions may aid in the better control and management of T2DM. If found true, it may shift the current intervention strategy towards liver rather than pancreas in the treatment of T2DM.



Journal: Medical Hypotheses

Keywords: Type 2 Diabetes, Liver dysfunction, Pancreas, Intra-organ communication
 

[Review Paper] Vaccines For Type 1 Diabetes: Prevention Or Reversal?

Abstract: Type 1 diabetes mellitus (T1DM) is an autoimmune disease which leads to destruction of pancreatic β-cells, thereby causing insufficient insulin production. Globally, around 98, 200 children and adolescents below 15 years of age and almost 128,900 subjects below 20 years of age develop T1DM annually, along with severe complications deteriorating their quality of life. In India alone, around 15,900 incident cases below 15 years have reported annually. Hence, its prevention and reversal are significant. Unlike other chronic diseases, T1DM involves the presence of various autoantigens which can be targeted by proper immunisation. The development of reliable immuno-regulatory surrogate markers would be of a great benefit. Vaccines can be one of such strategies in the journey to prevent T1DM. It would not only benefit greatly to reduce the sufferings caused due to diabetic complications but could also help to reverse T1DM, by modulating the immunological autoantigenic reactions and prevent further degradation of pancreatic β-cells. This review collates a wide range of information related to the vaccine studies conducted in animal and human models to prevent and reverse T1DM. 




Journal: Current Diabetes Reviews 

Keywords: Antigen vaccine; BCG vaccine; Immunomodulation; Micro-organisms; Type 1 diabetes mellitus; Vaccine 

[Review Paper] A Peripheral Concept On Aetiology Of Type 1 Diabetes Mellitus

Abstract: Diabetes mellitus is a common metabolic disorder affecting a wide range of population worldwide. There are many types of diabetes mellitus, one of which is type 1 diabetes mellitus (T1DM). It is an autoimmune disorder caused in about 97,700 children in India and 490,000 children globally. Many etiological factors contribute to this disease. This review article is a collage of etiological factors causing T1DM. A better understanding of the aetiology is significant for prevention and management of the disease.


Journal: Pharmaceutical Resonance 

Keywords: Type 1 Diabetes Mellitus; Etiology; Autoantibodies; Extracellular matrix; Coxsackievirus B virus

[Review Paper] Mapping Of Type 1 Diabetes Mellitus

Abstract: Type 1 diabetes mellitus (T1DM), an autoimmune disorder, is becoming widespread with approximately 97,700 children in India and 490,000 children worldwide affected. There are various etiological factors contributing to the expansion of its incidence in different geographical locations. Hence, the articles published in reputed journals were studies and data was collected for analyzing etiology and prevention of T1DM. It has been observed that hybrid insulin peptides act as key antigens for the autoreactive T cells and causes loss of self-tolerance in humans. The association of coxsackievirus B has been observed with the onset of T1DM. Accurate identification of the trigger can lead to the development of appropriate preventive measures. It can become a base for advance studies to prevent T1DM in humans. This review will highlight the causes and some preventive actions which can be considered to eliminate T1DM.


Journal: Current Diabetes Reviews

Keywords: Type 1 diabetes mellitus; coxsackievirus B virus; etiology; pathogenesis; prevention

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TESTIMONIALS

Dr. Shivani Desai is a thorough professional with strong Ethics. She has a keen interest in the field of Diabetes and also possesses an elaborate knowledge of Pre-clinical and Clinical Research.

Dr. Shivani Desai is passionate towards work and is an invaluable asset to any Institution or organization. I wish her all the success in personal and professional life.

Dr Hitt Sharma

TESTIMONIALS

Dr Shivani Desai is a hardcore researcher. Research is her birthright as she is born on National Science Day (28 Feb). She is passionate and deeply involved in Diabetes Research. She wishes to devote her entire career to converting Diabetes "Type 1 to Type None" following the slogan of JDRF.

Dr Ramesh Bhonde

TESTIMONIALS

Dr. Shivani Desai is self-motivated, perceptive, a sharp individual and takes that extra effort to achieve her goal. Her openness to feedback means she’s always learning and growing as a learner, an impressive strength that will continue to serve her well in her professional career and beyond. Rarely do you come across someone who is talented at both big picture ideas and executing the small details — Shivani is just that person.

Dr Hitt Sharma

TESTIMONIALS

Dr Shivani Desai plans to develop a poly vaccine for the prevention and better control of Type 1 diabetes. I am very much impressed by her keen interest to learn new aspects of diabetes. Her research zeal is evident from her recent publications in a span of one year.

Dr Ramesh Bhonde
Contact Us
Dr Shivani Desai
+91-20-49300148
Pune, India