Type 1 Diabetes Research

A Step Into Freedom From T1DM

About Me

Hello

I amShivani Desai

Type 1 diabetes researcher and enthusiast

Welcome to T1DM.org! It is a platform which consolidates my work about type 1 diabetes (T1DM) and its management. This forum invites an open interaction from national and international experts to manage type 1 diabetes, share their knowledge and collaborate to work towards freedom from this painful disease.

This forum includes the papers published by the author in the journals of repute. These papers primarily involve the content related to the etiology and pathophysiology of T1DM, the application of mesenchymal stem cells to manage T1DM and improve the quality of life in patients, and the correlation of diabetes with hepatic dysfunctions. It also includes papers related to the immunological aspects in the journey to prevent and reverse the disease.

With more interaction and collaborations, we can bring an end to T1DM and give a better life to the children who are at risk to develop this immensely agonising disease.

2 Patents

Diabetec foot ulcer (DFU) treatment using stem cell, Wound healing

26 Publications

T1DM vaccine research, Regenerative medicine research, 15 under process

10 Awards

'Woman Innovator' National Award 2022 and others, for research in T1DM

Journey So Far

2016

July

Inception of Idea

Development of vaccine to prevent and reverse type 1 diabetes mellitus

2018

September

t1dm.org Launched

Platform launched to consolidate research work about type 1 diabetes and its management

t1dm.org invites an open interaction from national and international experts to manage type 1 diabetes, share their knowledge and collaborate to work towards freedom from this painful disease

2020

June

Research Publication

First review paper on type 1 diabetes mellitus “Mapping of type 1 diabetes mellitus” published in Current Diabetes Reviews

2021

December

Preclinical Model Development

Preclinical model development project using Swiss albino mice started to study type 1 diabetes

2022

April

Phase 1 Preclinical Study

Stability test for vaccine formula conducted
Allergy test and safety study for vaccine formula conducted
Efficacy study of vaccine formula to prevent and reverse type 1 diabetes mellitus

My Latest Publications

Showing posts with label PancreasIntra-organ communication. Show all posts
Showing posts with label PancreasIntra-organ communication. Show all posts

[Review Paper] Treat Liver To Beat Diabetes



Abstract: Management of Type 2 Diabetes (T2DM) with existing strategies of lifestyle and pharmaceutical interventions has gained limited success as evidenced by its uncontrolled progression. Two key organs which are involved in the pathophysiology of T2DM are the liver and pancreas, both are the derivatives of endoderm with a common precursor. In the invertebrates, the hepatopancreas performs the function of both the liver and pancreas. It is known that derangement in glycolysis, neoglucogenesis, and glycogenolysis lead to hyperglycemia in T2DM although insulin levels are high. Several studies have reported the implication of abnormal liver function in the development of metabolic syndrome i.e. T2DM. Partial hepatectomy has been shown to improve glycemic status in animal models of diabetes. This could be because the liver and pancreas share the same regenerating factors. These pieces of evidence suggest that abnormal liver status can impair pancreatic beta-cell function and survival along with peripheral insulin resistance. We, therefore, hypothesize that restoring deranged liver functions may aid in the better control and management of T2DM. If found true, it may shift the current intervention strategy towards the liver rather than the pancreas in the treatment of T2DM.

Journal: Medical Hypotheses

Keywords: Type 2 Diabetes, Liver dysfunction, Pancreas, Intra-organ communication
 

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SHIVANI DESAI
+91-20-4930-0148
Pune, India