A FORUM TO

TYPE 1 DIABETES MELLITUS

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A Step Into Freedom From Type 1 Diabetes

T1DM.org

T1DM.org is a platform which consolidates the author’s work about type 1 diabetes and its management. This forum invites an open interaction from national and international experts to manage type 1 diabetes, share their knowledge and collaborate to work towards freedom from this painful disease.

This forum only includes the papers published by the author in the journals of repute at the moment. These papers primarily involve the content related to the etiology and pathophysiology of T1DM, application of mesenchymal stem cells to manage T1DM and improve the quality of life in patients, and about the correlation of diabetes with hepatic dysfunctions. However, it will soon come up with the papers related to the immunomodulatory aspects in the journey to prevent and reverse the disease.

With more interaction and collaborations, we can bring an end to T1DM and give a better life to the children who are at risk to develop this immensely agonising disease.

OUR APPROACH

1. In-vitro Study

Test the immunological reactions

2. Preclinical Study

Test the immunological responses in animal model

3. Formulation

Prepare a potential formulation candidate based on results and tests in in-vivo

4. Clinical Study

Clinical evaluation of the potential formation for T1DM
OUR T1DM PUBLICATIONS
Showing posts with label PancreasIntra-organ communication. Show all posts
Showing posts with label PancreasIntra-organ communication. Show all posts

[Review Paper] Treat Liver To Beat Diabetes

Abstract: Management of Type 2 Diabetes (T2DM) with existing strategies of lifestyle and pharmaceutical interventions has gained limited success as evidenced by its uncontrolled progression. Two key organs which are involved in the pathophysiology of T2DM are liver and pancreas, both are the derivatives of endoderm with a common precursor. In the invertebrates, hepatopancreas performs the function of both liver and pancreas. It is known that derangement in glycolysis, neoglucogenesis, and glycogenolysis lead to hyperglycemia in T2DM although insulin levels are high. Several studies have reported the implication of abnormal liver function in the development of metabolic syndrome i.e. T2DM. Partial hepatectomy has been shown to improve glycemic status in animal models of diabetes. This could be because liver and pancreas share the same regenerating factors. These evidences suggest that abnormal liver status can impair pancreatic beta-cell function and survival along with peripheral insulin resistance. We, therefore, hypothesize that restoring deranged liver functions may aid in the better control and management of T2DM. If found true, it may shift the current intervention strategy towards liver rather than pancreas in the treatment of T2DM.



Journal: Medical Hypotheses

Keywords: Type 2 Diabetes, Liver dysfunction, Pancreas, Intra-organ communication
 

Contact Us
Dr Shivani Desai
+91-20-49300148
Pune, India