Keywords: Type 1 Diabetes Mellitus; Etiology; Autoantibodies; Extracellular matrix; Coxsackievirus B virus
Showing posts with label etiology. Show all posts
Showing posts with label etiology. Show all posts
Abstract: Diabetes mellitus is a common metabolic disorder affecting a wide range of populations worldwide. There are many types of diabetes mellitus, one of which is type 1 diabetes mellitus (T1DM). It is an autoimmune disorder caused in about 97,700 children in India and 490,000 children globally. Many etiological factors contribute to this disease. This review article is a collage of etiological factors causing T1DM. A better understanding of aetiology is significant for the prevention and management of the disease.
Keywords: Type 1 Diabetes Mellitus; Etiology; Autoantibodies; Extracellular matrix; Coxsackievirus B virus
Abstract: Type 1 diabetes mellitus (T1DM), an autoimmune disorder, is becoming widespread with approximately 97,700 children in India and 490,000 children worldwide affected. There are various etiological factors contributing to the expansion of its incidence in different geographical locations. Hence, the articles published in reputed journals were studies and data was collected for analyzing the aetiology and prevention of T1DM. It has been observed that hybrid insulin peptides act as key antigens for the autoreactive T cells and causes loss of self-tolerance in humans. The association of coxsackievirus B has been observed with the onset of T1DM. Accurate identification of the trigger can lead to the development of appropriate preventive measures. It can become a base for advanced studies to prevent T1DM in humans. This review will highlight the causes and some preventive actions which can be considered to eliminate T1DM.
Journal: Current Diabetes Reviews
Keywords: Type 1 diabetes mellitus; coxsackievirus B virus; etiology; pathogenesis; prevention
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[Review Paper] Mapping Of Type 1 Diabetes Mellitus
Dr. Shivani Desai
October 04, 2019
![[Review Paper] Mapping Of Type 1 Diabetes Mellitus](https://1.bp.blogspot.com/-ShSK4maculU/YCqjwUwgg7I/AAAAAAAAE8o/K-bCPivf0cASOxd8aFmW2RutiiQSW4CnACLcBGAsYHQ/s72-c/MAPPING%2BOF%2BTYPE%2B1%2BDIABETES%2BMELLITUS.jpg)
T1DM is allied with the selective destruction of insulin-producing β-cells in the pancreas. The commencement of clinical disease signifies the end stage of β-cell destruction which leads to T1DM. There is marked heterogeneity of the pancreatic lesions, which makes it difficult to follow the pathogenesis of selective β-cell destruction within the islet in T1DM1.
Type 1 Diabetes Mellitus: Aetiology And Pathogenesis
Dr. Shivani Desai
November 05, 2018
