A FORUM TO

TYPE 1 DIABETES MELLITUS

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A Step Into Freedom From Type 1 Diabetes

T1DM.org

T1DM.org is a platform which consolidates the author’s work about type 1 diabetes and its management. This forum invites an open interaction from national and international experts to manage type 1 diabetes, share their knowledge and collaborate to work towards freedom from this painful disease.

This forum only includes the papers published by the author in the journals of repute at the moment. These papers primarily involve the content related to the etiology and pathophysiology of T1DM, application of mesenchymal stem cells to manage T1DM and improve the quality of life in patients, and about the correlation of diabetes with hepatic dysfunctions. However, it will soon come up with the papers related to the immunomodulatory aspects in the journey to prevent and reverse the disease.

With more interaction and collaborations, we can bring an end to T1DM and give a better life to the children who are at risk to develop this immensely agonising disease.

OUR APPROACH

1. In-vitro Study

Test the immunological reactions

2. Preclinical Study

Test the immunological responses in animal model

3. Formulation

Prepare a potential formulation candidate based on results and tests in in-vivo

4. Clinical Study

Clinical evaluation of the potential formation for T1DM
OUR T1DM PUBLICATIONS
Showing posts with label Antibiotics. Show all posts
Showing posts with label Antibiotics. Show all posts

[Review Paper] Antibiotics - A Boon Or Tragedy For Type 1 Diabetes?

Abstract: Type 1 diabetes mellitus (T1DM), an autoimmune disease, leads to obliteration of
pancreatic β-cells, and hence causes insufficient production of insulin. With many other etiological factors, antibiotic use and gut microbiota have a significant role to play in its development. The gut microbiota interacts with the cells involved in innate immunity and has a significant role in determining the immune system. Several factors such as mode of birth, infections, diet, and medication including antibiotics influence the microbiota composition. Alterations and manipulation of microbiota in animal models have shown to affect the onset and incidence of disease having multifactorial etiology, like T1DM. Hence, the microbiota is an integral part which influences the innate immune cells and this microbiota is influenced by the use of antibiotics. This review discusses the studies in relation to the microbiota and antibiotic use with reference to T1DM.




Journal: Pharmaceutical Resonance 

Keywords: Type 1 diabetes mellitus; Antibiotics; Microbiota; Innate immunity

Contact Us
Dr Shivani Desai
+91-20-49300148
Pune, India